Leads (267 results)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EGFR IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EGFR as well as the biological activity of IL2. An in vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity, and IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytok ... read more »

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM De-glycosylated dI-IgG-ala to IL2 (D20T). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2 (D20T). Deglycosylation of an Ig fusion protein generally was observed to have the effect of enhancing the ?-phase of a PK profile. This immunocytokine was designed for treating solid tumor. http://www.cr ... read more »

The Hepatitis E Virus ORF2 antigen contains a high basic amino acid content, suggesting that it may be involved in the encapsidation of the genomic RNA by effectively neutralizing the negatively charged RNA. ... read more »

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. The fusion protein displays an excellent tumor targeting performance in vivo. Considering the fact that the tumor targeting ability of scFv (L19) in patients with cancer has been demonstrated using scintigraphic methods, and that scFv ... read more »

Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer a full range of therapeutic antibodies currently available for research of a wide variety of diseases. We guarantee generated endotoxin free antibodies are fully functional and ready to use in animal-based assays and clinical trials. ... read more »

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA scFv to IL10. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL10. For this fusion protein, a selective targeting of arthritic lesions and neovascular tumor structures in mice was observed. In a collagen-induced arthritis model in mice, F8-IL10 was also able to inhibit progression of established arth ... read more »

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Hydrolyses the terminal 2-O-sulphate on the unsaturated di-and oligo-saccharides produced by the action of lyases on sulphated glycosaminoglycans. http://www.creative-enzymes.com/product/Native-Flavobacterium-Heparinum-2OSulfatase_1558.html ... read more »

In enzymology, a peptide-N4-(N-acetyl-beta-glucosaminyl) asparagine amidase (EC 3.5.1.52) is an enzyme that catalyzes a chemical reaction that cleaves a N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in l ... read more »

The Human CTRP1 ELISA is a sandwich enzyme immunoassay for the quantitative measurement of human CTRP1 protein. Store components of the kit at 2-8°C or -20°C upon arrival up to the expiration date. For more detailed information, please download the following document on our website. http://www.creative-diagnostics.com/Human-CTRP-1-ELISA-Kit-106114-501.htm ... read more »